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. 2007 Jun 25;104(27):11465–11470. doi: 10.1073/pnas.0704757104

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© 2007 by The National Academy of Sciences of the USA

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Fig. 4. — Cumulative frequency analysis of aging and treatment effects on spine size: H_d, H_l, and N_l. (A) Significant aged related increases of H_d were observed between the aged (OVX+Veh and OVX+E) vs. young (OVX+Veh and OVX+E) groups (P < 0.0001). Although a highly significant treatment effect was observed in the aged group (P < 0.005), i.e., H_d decreased following treatment, a marginally significant difference was observed in young animals (P = 0.02). (B) No aging and treatment effects on H_l were observed. (C) Overall, aging significantly reduced N_l (P < 0.0001). Although no treatment effects on N_l were observed within the aged group, a marginally significant increase in N_l was observed in the young OVX+E compared with young OVX+Veh group (P = 0.015).