Table 3.
Associations of log total testosterone (T), log free androgen index (FAI) and log dehydroepiandrosterone sulfate (DHEAS) with biochemical, physical and neuropsychological variables. Data presented are Pearson correlation coefficients (R) and associated P-values from linear regression analysis
| Log T | Log FAI | Log DHEAS | ||||
|---|---|---|---|---|---|---|
| R | P-value | R | P-value | R | P-value | |
| Biochemical | ||||||
| Log CRP | 0.166 | 0.01 | 0.21 | 0.001 | 0.24 | 0.0001 |
| Log adiponectin | - 0.23 | 0.0003 | - 0.30 | < 0.0001 | - 0.208 | 0.001 |
| Log triglycerides | 0.067 | 0.30 | 0.13 | 0.042 | - 0.067 | 0.301 |
| Leptin | 0.07 | 0.25 | 0.14 | 0.031 | 0.026 | 0.686 |
| Log sIL2r | 0.065 | 0.314 | 0.02 | 0.778 | - 0.047 | 0.469 |
| Log sIL6r | 0.005 | 0.937 | - 0.004 | 0.947 | 0.028 | 0.667 |
| Log sTNFr1 | 0.11 | 0.084 | 0.07 | 0.289 | - 0.175 | 0.007 |
| Log sTNFr2 | 0.06 | 0.349 | 0.01 | 0.843 | - 0.28 | < 0.0001 |
| Glucose | 0.05 | 0.44 | 0.14 | 0.035 | 0.037 | 0.58 |
| Physical | ||||||
| Systolic BP | 0.06 | 0.334 | 0.03 | 0.646 | - 0.01 | 0.882 |
| Diastolic BP | 0.125 | 0.053 | 0.09 | 0.149 | 0.09 | 0.153 |
| BMI | 0.19 | 0.003 | 0.25 | 0.0001 | 0.188 | 0.004 |
| Waist circumference | 0.238 | 0.01 | 0.28 | 0.002 | 0.19 | 0.035 |
| Max. grip strength | - 0.002 | 0.979 | 0.03 | 0.622 | 0.013 | 0.851 |
| BADL’s | - 0.006 | 0.927 | - 0.019 | 0.772 | - 0.05 | 0.395 |
| IADL’s | - 0.021 | 0.75 | - 0.026 | 0.692 | - 0.13 | 0.041 |
| Nagi upper body | 0.036 | 0.583 | 0.016 | 0.807 | - 0.05 | 0.439 |
| Nagi lower body | 0.06 | 0.359 | 0.046 | 0.476 | - 0.11 | 0.081 |
| YPAS | - 0.11 | 0.083 | -0.095 | 0.141 | - 0.06 | 0.314 |
| Sit-stand test | 0.08 | 0.451 | 0.11 | 0.284 | - 0.10 | 0.338 |
| 6 meter walk time | - 0.235 | 0.027 | - 0.17 | 0.106 | - 0.12 | 0.25 |
| 6 minute walk distance | - 0.256 | 0.016 | - 0.26 | 0.013 | - 0.048 | 0.652 |
| Peak torque/body weight (120°) | ||||||
| ankle extensors | - 0.18 | 0.062 | - 0.23 | 0.018 | - 0.08 | 0.487 |
| ankle flexors | - 0.069 | 0.484 | - 0.11 | 0.264 | 0.002 | 0.986 |
| knee extensors | - 0.21 | 0.031 | - 0.238 | 0.015 | 0.02 | 0.813 |
| knee flexors | - 0.17 | 0.079 | - 0.155 | 0.144 | - 0.015 | 0.876 |
| hip extensors | - 0.10 | 0.335 | - 0.129 | 0.214 | 0.11 | 0.28 |
| hip flexors | - 0.147 | 0.155 | - 0.169 | 0.101 | - 0.08 | 0.442 |
| Total skeletal mass | ||||||
| fat mass/height | 0.325 | 0.0005 | 0.38 | < 0.0001 | 0.216 | 0.021 |
| lean mass/height | 0.317 | 0.0007 | 0.37 | 0.0001 | 0.246 | 0.009 |
| Appendicular skeletal mass | ||||||
| total | 0.316 | 0.0007 | 0.36 | 0.0001 | 0.226 | 0.016 |
| percent lean | - 0.19 | 0.041 | - 0.22 | 0.018 | - 0.12 | 0.197 |
| Bone mineral density | ||||||
| Cervical spine | 0.28 | 0.002 | 0.31 | 0.0007 | 0.19 | 0.036 |
| Trochanter | 0.26 | 0.004 | 0.30 | 0.001 | 0.185 | 0.046 |
| Intertrochanter | 0.257 | 0.006 | 0.27 | 0.003 | 0.228 | 0.014 |
| Total hip | 0.28 | 0.002 | 0.30 | 0.001 | 0.22 | 0.017 |
| Lumbar spine | 0.265 | 0.004 | 0.29 | 0.002 | 0.245 | 0.008 |
| Neuropsychological | ||||||
| MMSE | 0.024 | 0.71 | 0.077 | 0.235 | 0.059 | 0.363 |
| TMT-A | - 0.07 | 0.464 | - 0.07 | 0.444 | - 0.063 | 0.515 |
| TMT-B | - 0.08 | 0.398 | - 0.085 | 0.388 | - 0.03 | 0.76 |
| TMT-B:TMT-A | - 0.13 | 0.18 | - 0.146 | 0.138 | 0.002 | 0.982 |
| CESD | - 0.10 | 0.114 | - 0.12 | 0.057 | - 0.15 | 0.018 |
CRP = C-reactive protein; sIL2r = soluble interleukin 2 receptor; sIL6r = soluble interleukin 6 receptor; sTNFr1 = soluble tumour necrosis factor receptor 1; sTNFr2 = soluble tumour necrosis factor receptor 2; BMI = body mass index; BADL = Basic activities of daily living; IADL = Instrumental activities of daily living; YPAS = Yale Physical Activity Survey; MMSE = Mini Mental State Examination; TMT-A = trail making test part A; TMT-B = trail making test part B; CESD = Center for Epidemiologic Studies Depression Scale.