Table 1.
Characteristics of the study cohorta
| Characteristic | Non-proteinuric (N=28) | Proteinuric (N=6) |
|---|---|---|
| Age, yrs | 45 (23, 62) | 49 (39, 59) |
| Male sex, n (%) | 19 (68) | 5 (83) |
| Black race, n (%) | 11 (39) | 3 (50) |
| Smokerb, % | 17 (61) | 3 (50) |
| Systolic blood pressurec, mmHg | 111 (97, 145) | 119 (108, 133) |
| Body mass index, kg/m² | 27 (19, 40) | 27 (19, 34) |
| Waist to hip ratio | 1.00 (0.87, 1.75) | 0.97 (0.91, 1.02) |
| CD4, cells/µL | 498 (12, 1534) | 535 (12, 1021) |
| HIV-1 RNA level < 400 copies/mLd, n (%) | 23 (82) | 2 (33) |
| Urine protein/creatinine, mg/mmol | 9.0 (3.4, 15.9) | 48.6 (27.1, 109.7) |
| Urine albumin/creatinine, mg/mmol | 0.5 (0.1, 5.6) | 12.8 (1.3, 29.8) |
| Creatinine clearancee, mL/min | 119 (72, 202) | 98 (65, 164) |
| Hepatitis C Ab positive, n (%) | 3 (12) | 1 (17) |
| Serum glucose, mmol/L | 5.2 (3.9, 6.6) | 4.9 (4.2, 6.1) |
| Serum triglyceride, mmol/L | 1.8 (0.7, 6.5) | 1.5 (0.9, 1.8) |
| Serum total cholesterol, mmol/L | 4.5 (3.0, 8.1) | 4.4 (3.8, 5.9) |
| Serum HDL-C, mmol/L | 0.8 (0.4, 1.4) | 1.5 (0.7, 2.6) |
| Serum LDL-C, mmol/L | 1.8 (0.9, 4.3) | 2.0 (0.5, 3.9) |
| Flow-mediated dilation, % | 4.8 (−4.2, 12.9) | 7.8 (0.4, 10.5) |
a
Values presented as median (range) except where noted. All laboratories were obtained after a 12 hour fast prior to endothelial function measurements. HDL=high density lipoprotein cholesterol; LDL=low density lipoprotein cholesterol.
b
Past or current tobacco use.
c
Mean of three values obtained at screening and main study visits.
d
p=0.03 for the difference between groups.
e
Estimated using Cockcroft-Gault equation.