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. 2007 Oct 31;1(1):e1. doi: 10.1371/journal.pntd.0000001

Figure 3. A. Overall structure of the TcTIM soaked in DTDA. B. Cysteine 118 is covalently bound to thiobenzylamine.

Figure 3

Panel A shows that the general structure of the TcTIM dimer is not altered by DTDA; monomers A and B are shown in green and blue, respectively and thioaniline in orange. The figures were prepared with PyMOL. In panel B, the derivatized Cys118 of monomer B is shown. FoFc map (3 σ) after the first refinement using CNS annealing and B refinement; a clear positive density that corresponds to covalently bound thioaniline is observed. The same data were observed in monomer A (not shown).