Table 6.
List of Mn-altered Genes That Are Regulated by the IFN-γ or EGF Signaling Pathway
| Gene Name | Fold Change | Common | Genbank | Description |
|---|---|---|---|---|
| IFNγ-regulated | ||||
| 202912_at | 3.8 | ADM* | NM_001124 | adrenomedullin |
| 208644_at | 0.5 | ADPRT | M32721 | ADP-ribosyltransferase |
| 202095_s_at | 0.4 | BIRC5 | NM_001168 | baculoviral IAP repeat-containing 5 |
| 208075_s_at | 3.1 | CCL7 | NM_006273 | chemokine (C-C motif) ligand 7 |
| 233137_at | 4.2 | CD48 | AF143887 | CD48 antigen (B-cell membrane protein) |
| 213003_s_at | 2.3 | CEBPD | BF061054 | CCAAT/ENHANCER BINDING PROTEIN DELTA |
| 209774_x_at | 4.1 | CXCL2 | M57731 | chemokine (C-X-C motif) ligand 2 |
| 204470_at | NM_001511 | |||
| 224239_at | 3.2 | DEFB103 | AF301470 | defensin, beta 103 |
| 203717_at | 2.8 | DPP4 | NM_001935 | dipeptidylpeptidase 4 |
| 207160_at | 4.2 | IL12A | NM_000882 | interleukin 12A |
| 215182_x_at | 2.5 | IL1R1 | AL050122 | |
| 221841_s_at | 3.2 | KLF4 | BF514079 | Kruppel-like factor 4 (gut) |
| 240338_at | 2.2 | LRAP | AI807341 | leukocyte-derived arginine aminopeptidase |
| 244704_at | 0.5 | NFYB | AW083948 | neuronal thread protein |
| 200790_at | 0.4 | ODC1 | NM_002539 | ornithine decarboxylase 1 |
| 1559400_s_at | 5.4 | PAPPA | BG620958 | |
| 211840_s_at | 0.4 | PDE4D | U50157 | phosphodiesterase 4D, cAMP-specific |
| 204748_at | 2.7 | PTGS2 | NM_000963 | prostaglandin-endoperoxide synthase 2 |
| 203110_at | 0.4 | PTK2B | U43522 | PTK2B protein tyrosine kinase 2 beta |
| 206157_at | 2.3 | PTX3 | NM_002852 | pentaxin-related gene, rapidly induced by IL-1 beta |
| 228037_at | 0.4 | RARA | AA404273 | retinoic acid receptor, alpha |
| 1568765_at | 2.3 | SERPINE1 | BC020765 | serine (or cysteine) proteinase inhibitor, clade E, member 1 |
| 237106_at | 2.2 | SLC11A2 | AI051244 | solute carrier family 11, member 2 |
| 215078_at | 12 | SOD2 | AL050388 | superoxide dismutase 2 |
| 212171_x_at | 2.0 | VEGF | H95344 | vascular endothelial growth factor |
| 211527_x_at | M27281 | |||
| EGF-regulated | ||||
| 221681_s_at | 2.0 | DSPP | AF094508 | Homo sapiens dentin phosphoryn mRNA, complete cds. |
| 236990_at | 0.2 | EIF2AK3 | AV699382 | cDNA clone |
| 205767_at | 8.7 | EREG | NM_001432 | epiregulin |
| 234240_at | 0.2 | GSN | AL049930 | Homo sapiens mRNA |
| 209957_s_at | 0.4 | NPPA | M30262 | natriuretic peptide precursor A |
| 233626_at | 4.3 | NRP1 | AK024580 | neuropilin 1 |
| 202730_s_at | 0.4 | PDCD4 | NM_014456 | programmed cell death 4 |
| 205934_at | 0.4 | PLCL1 | NM_006226 | phospholipase C-like 1 |
| 217705_at | 2.6 | PRKCM | AW085172 | protein kinase C, mu |
| 202388_at | 2.1 | RGS2 | NM_002923 | regulator of G-protein signalling 2 |
| 220983_s_at | 2.1 | SPRY4 | NM_030964 | sprouty homolog 4 |
*
The italicized genes are those known to be activated by INF-γ and were up-regulated by Mn