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. Author manuscript; available in PMC: 2008 Sep 15.
Published in final edited form as: Bioorg Med Chem. 2007 Jun 13;15(18):6253–6261. doi: 10.1016/j.bmc.2007.06.020

Figure 2.

Figure 2

A panel of peptides bearing aldehyde functional groups was synthesized based upon the DQ2-αI (1) and DQ2-αII (7) gluten peptides. Substitutions were made at both the P4 and P6 HLA-DQ2 binding positions of the peptides. Further, the side-chain length was varied to find the binding optimum. Based upon the binding results of peptides 1−11, putatively optimal aldehyde substitutions were made in the 20mer gluten peptide (12). All peptides are labeled at the N-terminus with the fluorophore 5(6)-carboxyfluorescein (designated f).

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