Skip to main content
. Author manuscript; available in PMC: 2008 Sep 15.
Published in final edited form as: Bioorg Med Chem. 2007 Jun 13;15(18):6253–6261. doi: 10.1016/j.bmc.2007.06.020

Figure 6.

Figure 6

Kinetic analysis of TG2 inhibition using aldehyde inhibitors. (A) Example of the reaction progress curves generated using a previously described continuous spectrophotometric assay for tracking TG2 activity.7 Straight lines were fit to the linear region of the data to determine the reaction rates. Increasing the concentration of peptide 18 decreased the linear reaction velocity of 15 mM ZQG in a dose dependent fashion. (B) Lineweaver-Burk plot indicating that TG2 inhibition using aldehyde inhibitor 18 is competitive. TG2 reaction velocities were measured at 10, 20, 30, and 40 mM ZQG in the presence of 0, 30, 100, or 250 μM inhibitor 18.

HHS Vulnerability Disclosure