Table 3.

Sequences and kinetic constants of peptides selected against PTP1B^a

Peptide	Peptide Sequence	kcat (s−1)	KM (μM)	kcat/KM (× 105 M−1 s−1)
11	KAVFIpYAA	16 ± 2	23 ± 6	7.0
12	KAIFLpYAA
13	KALHGpYAA
14	KSVENpYAA
15	RAMLMpYAA
16	RTINEpYAA	12 ± 1	18 ± 1	6.9
17	RTIEWpYAA	7.8 ± 0.1	26 ± 1	3.0
18	VPGEWpYAA
19	TMHEWpYAA
20	MGDEQpYAA
21	QEDEPpYAA	8.3 ± 0.6	20 ± 5	4.1
22	DRRVApYAA
23	DLVSApYAA

^aM, norleucine. PTP assay was performed in 100 mM Hepes (pH 7.4), 100 mM NaCl, 2 mM EDTA, and 5 mM TCEP.