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. Author manuscript; available in PMC: 2008 Aug 10.

Published in final edited form as: J Mol Biol. 2007 Jun 2;371(2):308–316. doi: 10.1016/j.jmb.2007.05.077

(A) Stability of the Bn domain of BU, reported by C_m values, as a function of the change in stability of free Ub, determined by ΔC_m values. ΔC_m is relative to free WT Ub. Circles represent the following variants, from left to right: V26G, V26A, K29N, K29Q, WT, R42E. Lines are simulated results using ΔG_X values of 3 kcal·mol⁻¹, 4 kcal·mol⁻¹ and 5 kcal·mol⁻¹(from upper to lower curves); see text for other parameters. (B) Stability of the Bn domain of BU as a function of the stability of free Bn. ΔC_m is relative to free WT Bn. Data points are, from left to right: I96A, I96V, WT. Solid lines are simulated results for ΔG_X values of 3 kcal·mol⁻¹, 4 kcal·mol⁻¹ and 5 kcal·mol⁻¹ (from left to right). Dashed line is the simulated result for ΔG_X = 0.

(A) Stability of the Bn domain of BU, reported by C_m values, as a function of the change in stability of free Ub, determined by ΔC_m values. ΔC_m is relative to free WT Ub. Circles represent the following variants, from left to right: V26G, V26A, K29N, K29Q, WT, R42E. Lines are simulated results using ΔG_X values of 3 kcal·mol⁻¹, 4 kcal·mol⁻¹ and 5 kcal·mol⁻¹(from upper to lower curves); see text for other parameters. (B) Stability of the Bn domain of BU as a function of the stability of free Bn. ΔC_m is relative to free WT Bn. Data points are, from left to right: I96A, I96V, WT. Solid lines are simulated results for ΔG_X values of 3 kcal·mol⁻¹, 4 kcal·mol⁻¹ and 5 kcal·mol⁻¹ (from left to right). Dashed line is the simulated result for ΔG_X = 0.