Table 3.

A comparison of the residues involved in calcium coordination in the DE loops of repeat I in alpha-11 giardin and other annexin structures.

Structure	Residues	Amino Acid Sequence
Alpha-11 giardin	53–62, 126 (monomer B)†	K	K	C	I	K	N	G	P	Y	E,*	D‡*
Annexin A1	97–106, 196 (monomer B)	K	K	A	L	T	G	H	L	E*	E,	D‡*
Annexin A2	88–97, 36 (monomer B)	K	S	A	L	S	G	H	L	E*	T,	E‡*
Annexin A5	75–84	K	S	E	L	T	G	K	F	E**	K
Annexin A6	70–79	K	Y	E	L	T	G	K	F	E	R

Residues involved in calcium coordination in the DE loop of repeat I are high-lighted in bold and colored red (backbone carbonyl oxygens), orange (polar side chain) and blue (acidic side chain: unidentate (*) and bidentate carboxylate (**)). Annexin PDB codes: A1 - 1MCX,¹⁸ A2 - 1XJL,¹⁹ A5 - 1AVR²⁰ and A6 - 1AVC.¹⁶

^†Calcium coordination from a neighboring molecule is only seen for monomer C.

^‡Residues from a neighboring molecule.