Figure 1. Phylogenetic Reconstruction of Nonecotropic MLV Proviruses in the C57BL/6J Genome.

A maximum likelihood analysis of codon adjusted internal region ORFs (gag, pol, and env) of nonecotropic MLVs and related reference sequences is shown. Bootstrap supports >60% are shown next to branch nodes. The Pmv and Mpmv proviruses are monophyletic and group separately from each other, while the Xmv proviruses form three clades, marked A, B, and C. The ecotropic endogenous provirus Emv 2 (MLV Eco), and the exogenous virus MoMLV are also included as outgroups, as is the Xmv-like retrovirus (HuXmv) recently described in human prostate cancer [50]. tRNA primer types inferred from the PBS sequences are noted by the symbols next to sequence names.