Table 1.

AKXD mouse, tumor, and VST information by strain

Statistics	Total	AKXD strain
		AK-2	AK-3	AK-9	AK-10	AK-13	AK-14	AK-16	AK-18	AK-27
Animals aged	469	32	96	32	29	58	14	71	63	74
Lymphomatous animals	204	7	57	18	4	18	4	13	42	41
% Tumor incidence	43	22	59	56	14	31	29	18	67	55
VST distribution
in high-confidence CISs	140	6	18	13	1	21	2	6	30	43
in single-hit CISs	25	0	5	1	0	5	0	3	4	7
single hits	237	13	53	18	7	28	6	25	40	47
with no BLAST hits	28	2	8	1	0	5	0	0	3	9
repeat sequence hits	120	2	30	19	1	21	2	6	10	29
endogenous site hits1	66	5	21	11	0	13	2	5	2	7
total identified	616	28	135	63	9	93	12	45	89	142

Number of animals aged, tumor incidence, and the number of VSTs varied by strain. VST data are broken down by results of genomic alignments and clustering analysis. VSTs that gave no significant BLAST result or mapped to repeat sequences were excluded from further study. Significant BLAST results were analyzed for clustering and multiple hit CISs were constructed. Several multiple-hit CISs were excluded as likely endogenous insertion sites. The remaining nonclustering single hits were compared to other viral mutation cancer screens to identify single-hit CISs (single hits in this screen that map to the location of previously identified CIS)