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. 2007 Oct 9;104(41):16032–16037. doi: 10.1073/pnas.0701309104

Fig. 2.

Fig. 2.

Condition-specific effects of propofol sedation on fMRI responses. (a) BOLD signal interaction between condition and sedation level rendered onto a canonical brain image. Results are thresholded at P < 0.05 FDR corrected (solid line on scale) within a search volume of areas responding to all sentences compared with SCN in awake participants. (b) Plot of BOLD signal changes compared with rest for high-ambiguity sentences, low-ambiguity sentences, and SCN at three levels of sedation from a peak voxel in the left IFG [solid white arrow in a, Montreal Neurological Institute (MNI) coordinates: x = −44, y = +22, z = +22]. Error bars show standard error of the mean excluding between-subject variability, appropriate for repeated-measures comparisons between conditions. Significance of two conditions by two sedation level interaction shown by braces (∗∗ reaches P < 0.05 FDR corrected, equivalent to P < 0.01 uncorrected; see SI Table 5 and SI Fig. 4). (c) BOLD signal in the left MTG (broken white arrow in a: x = −62, y = −34, z = −4), plotted as in b. ∗ interaction reaches P < 0.05 uncorrected. (d) BOLD signal in the left PCG (solid black arrow in a: x = −50, y = 0, z = +50).