Fig. 3.
Effects of sedation on sentence memory. (a) d′ recognition-memory performance at three levels of sedation (awake, light sedation, and deep sedation). Error bars show the standard error of the mean over subjects. Memory was above chance for sentences presented to awake and lightly sedated participants (∗∗∗, P < 0.001), although not for deeply sedated participants. Sentence recognition was impaired by light sedation [awake vs. light: t (10) = 6.16, P < 0.001] and further impaired during deep sedation [light vs. deep: t(10) = 4.13, P < 0.005]. (b) Brain regions showing a signification correlation between activity for sentences compared with SCN and recognition-memory performance during light sedation, thresholded at P < 0.05 FDR corrected (solid line on scale) within the same search volume as a. (c) BOLD response for sentences vs. SCN against d′ recognition-memory score for the left IFG [arrow in b, Montreal Neurological Institute (MNI) coordinates: x = −50, y = +28, z = −16]. The dashed line shows the best-fitting linear regression line (y = 0.023x − 0.013).