Fig. 5.

Survival of mice was increased in mice administered follistatin before a dose of LPS that causes significant shock and death. (A) Mice administered follistatin before LPS (FS, open circles) displayed an increased survival compared with LPS alone (filled circles). (B) Activin A levels in the circulation of mice treated with the lethal dose of LPS, irrespective of follistatin administration, correlate with outcome, with significantly (P < 0.001) higher concentrations in those animals that died compared with those that survived the endotoxemia. The dotted line shows that there were no overlapping values between the two outcomes.