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. 2007 Oct 3;104(41):16335–16340. doi: 10.1073/pnas.0701471104

Fig. 7.

Fig. 7.

MDMA-induced anorexia-like behavior in starved mice was reduced when CART was knocked down in the NAc by using siCART. Data are means ± SEM of total food intake for 1 h. (A) WT mice treated with saline or BIMU8 injected alone (n = 14–14) or combined with the siCART control (n = 15) or siCART (n = 10) into the NAc. (B) WT mice treated with an i.p. injection of saline or MDMA plus an intraaccumbal infusion of siCART control (n = 8 and 14, respectively) or siCART (n = 14 and 12, respectively). Treatments that differ significantly from NaCl are noted (§, P < 0.05; §§§, P < 0.0001). Significant differences between siCART and siCART control are marked (*, P < 0.05; **, P < 0.01). There was a significant interaction between both modes of injection (#, P < 0.05).