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. 2007 Oct 2;104(41):16341–16346. doi: 10.1073/pnas.0705756104

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© 2007 by The National Academy of Sciences of the USA

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Fig. 4. — The EPSC steady-state rate is sensitive to fast and slow Ca²⁺ buffering in the IHC. (A1–A3) Simultaneous recordings of IHCs and AFs using different IHC Ca²⁺ buffers; in 100 μM CTZ, 1-s IHC depolarization, V_c: −89 to −29 mV. (B) For different buffer conditions, EPSC steady-state rates were significantly different (#, P = 0.01), whereas EPSC amplitudes were not (1 mM EGTA: 253.9 ± 35.1 pA, n = 6, 179 EPSCs; 5 mM EGTA: 315 ± 51.8 pA, n = 4, 87 EPSCs; 5 mM BAPTA: 220 ± 27.8 pA, n = 3, 67 EPSCs, ANOVA, P = 0.35, mean values and SE). Ca²⁺ current amplitudes were not significantly different (1 mM EGTA: 160.4 ± 13.5 pA, n = 6, 96 depolarizations; 5 mM EGTA: 171.2 ± 4.7 pA, n = 4, 66 depolarizations; 5 mM BAPTA: 165.1 ± 25.3 pA, n = 4, 93 depolarizations, ANOVA, P = 0.89).