Fig. 3.
Recombinant vaccinia encoding a model TAA (β-gal) induces TAA-specific immunity in vivo against RM-1 prostate cancer cells. C57BL/6 mice were immunized with 107 plaque forming units/mouse of rVV-β-gal (filled symbols) or control vector V69 (open symbols).Three weeks later, immunized mice were challenged with 105 D7RM-1 tumor cells subcutaneously and followed up for tumor-related death (n=10 mice per therapy group; P=0.002). Similar findings confirmed in three separate experiments.