Figure 1.

Schematic representation of the two constructs used for transgenesis. The arrangement of the transcription factor binding sites in the glucocorticoid regulated enhancers is shown by the presence of the corresponding factors, represented by symbols as indicated. The three differently hatched boxes represent the other segments shared by the two constructs; RPII, RNA polymerase II gene promoter; CAT, CAT coding region; 3′ β-globin, last intron and polyadenylylation site of the rabbit β-globin gene (for details, see ref. 14).