Figure 5.

Functional use of γ-cyclodextrin to reverse exogenous steroid effects in neurons. (a) The ipscs generated from autaptic hippocampal neurons cultured in synaptic isolation. γ-Cyclodextrin (0.5 mM) has little effect on ipscs under basal conditions. (b) In the same cell as in (a), the ipsc is prolonged by 100 nM 3α5αP in the absence, but not in the presence of 0.5 mM γ-cyclodextrin. The dotted trace is a re-plot of the baseline ipsc from (a).