Figure 7.

Role of contractile prostaglandin receptor stimulation in insulin-induced airway smooth muscle contraction. Insulin (1 μM)-induced contractions were recorded in the absence and presence of indomethacin (3 μM), the FP-receptor antagonist AL-8810 (10 μM) or the EP₁-receptor antagonist AH-6809 (10 μM). Responses shown in (b) are corrected for inherent myogenic tone and are derived from the data shown in (a). All data shown represent means and s.e.m. (vertical lines) of three experiments. ^*P<0.05; ^**P<0.01; ^***P<0.001 compared to control. ^##P<0.01; ^###P<0.001 compared to the control insulin response.