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. 2006 Dec 18;150(2):220–226. doi: 10.1038/sj.bjp.0706968

Figure 4.

Figure 4

Effects of various pharmacological treatments with single drugs (ODQ and TTX), or with a combination of drugs (L-NAME+ZnPP-IX or L-NAME+ZnPP-IX+ODQ) on EFS-induced NANC relaxations evoked by frequencies of 3 and 10 Hz in the guinea-pig isolated whole trachea. For comparison purposes, the effect of L-NAME (as already presented in Figure 2) on both the amplitude (a) and the AUC (b) of the inhibitory responses has also been included. L-NAME+ZnPP-IX significantly reduced both the amplitude and the AUC of NANC responses either vs control relaxations or vs L-NAME alone (with the exception of the amplitude of relaxations elicited at 3 Hz). The effect of ODQ alone was similar to that of L-NAME+ZnPP-IX. The combination of L-NAME+ZnPP-IX+ODQ inhibited the responses in terms of amplitude and AUC to an extent similar to that of TTX (1 μM). Data represent mean and vertical lines show s.e.m. of 4–10 experiments. *P<0.05, **P<0.01.