Table 2.
Echocardiographic measurements at week 10
| Sham | Sham | MI | MI | |
|---|---|---|---|---|
| placebo | SB 239063 | placebo | SB 239063 | |
| n | 13 | 14 | 5 | 9 |
| Heart rate (b.p.m.) | 232±8 | 229±5 | 235±4 | 233±17 |
| Papillary | ||||
| ESD (mm) | 5.21±0.34 | 5.66±0.46 | 8.44±0.57** | 7.76±0.74** |
| EDD (mm) | 8.12±0.25 | 8.65±0.29 | 10.60±0.54** | 9.91±0.49** |
| FS (%) | 36.6±2.3 | 35.6±3.3 | 20.6±1.6* | 23.3±4.5* |
| Apical | ||||
| ESD (mm) | 4.83±0.39 | 5.55±0.51 | 8.34±0.57** | 7.57±0.81** |
| EDD (mm) | 7.85±0.26 | 8.05±0.26 | 10.14±0.44** | 9.52±0.43** |
| FS (%) | 37.7±2.3 | 36.5±2.9 | 17.4±2.8** | 21.3±3.5** |
Abbreviations: EDD, end-diastolic diameter; ESD, end-systolic diameter; FS, fractional shortening.
Data are mean±s.e.m., n indicates number of animals studied.
*
P<0.05
**
P<0.01 sham vs MI.