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Effects of PAR4-activating peptide (PAR4-AP) AYPGKF-NH2 or control peptide YAPGKF-NH2 (both 50 μg per paw), on withdrawal latency and nociceptive threshold in response to thermal stimulus (a) and to a mechanical stimulus (b). PAR4-AP caused a significant increase of thermal and mechanical nociceptive thresholds. Data represent mean and vertical lines show s.e.m. *Significantly different from basal (time 0) for P<0.05 (n=8 rat per group).
