Figure 7.

Effects of i.pl. co-injection of carrageenan and selective PAR₄-activating peptide (PAR₄-AP) or control peptide (each 50 μg per paw) on carrageenan-induced inflammatory hyperalgesia and allodynia. Kinetics of nociceptive functions, in response to a thermal (a, withdrawal latency) or a mechanical (b–d, von Frey filament exposure) stimulus, were followed before (time 0) and at different times (in minutes) after i.pl. injection. For all, symbols represent the mean and vertical lines show s.e.m., n=8 rats per group, and ^*P<0.05 compared with the control peptide.