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(a) Individual Poincaré plots showing increased STV(QT) after combined IKs+IKr block in dogs that later developed TdP but (b) no change in STV(QT) when TdP did not occur. IKs, the slow component of the delayed rectifier potassium current; IKr, the rapid component of the delayed rectifier potassium current; STV(QT), short-term variability of the QT interval.
