Skip to main content
. Author manuscript; available in PMC: 2008 Sep 1.
Published in final edited form as: Exp Neurol. 2007 Jun 19;207(1):118–127. doi: 10.1016/j.expneurol.2007.06.003

Figure 3. [3H]DAA1106 specific binding correlates with the abundance of activated microglia but not astrocytes.

Figure 3

A–B, Combined immunostaining for activated microglia (CD68, green) and astrocytes (GFAP, red) was performed in cortical brain tissue in rats with CCI at the side ipsilateral to the contusion (A) and the contralateral side (B). The ipsilateral side showed prominent activation of microglia and astrocytosis (A) compared to the contralateral side (B). Scale bar indicates 50 μm.

C, Activated microglia (CD68, black bars, left Y-axis, p=0.0491) and astrogliosis (GFAP, clear bars, right Y-axis, p=0.04615) were significantly higher on the side ipsilateral to the lesion compared to the contralateral side. Data was analyzed using student’s t test, *p<0.05.

D–E, [3H]DAA1106 Specific binding (Bmax, X-axis) correlated with the abundance of microglia (D, CD68, black squares, r=0.8989, p=0.0148), but not with the abundance of astrocytes (E, GFAP, clear squares, r=0.5385, p=0.2703).

HHS Vulnerability Disclosure