Figure 5. [11C]DAA1106 is retained at greater levels at the site of the lesion compared to [11C](R)-PK11195 in rats with TBI.
Rats with CCI were injected with either [11C]DAA1106 or [11C](R)-PK11195 (1–2mCi) intravenously. A 30-minute uptake period was allowed after radiotracer injection, following which animals were sacrificed and brain tissue was processed for ex-vivo autoradiography. Uptake of [11C]DAA1106 at the site of lesion (A) is greater than [11C](R)-PK11195 uptake (B).