Figure 3.

ONOO⁻ inhibition reduces bacterial count in blood from mice with sepsis. Mice were in sham, MSI and SSI groups. Bacterial count in blood was determined 6 h after CLP. Animals were pretreated, s.c., with saline or UA (100 mg kg⁻¹) 1 h before SSI. Results are expressed as median of log CFU per ml of blood, (n=5 animals per group). ^*P<0.05 compared to Sham group; ^#P<0.05 compared to MSI group; ^**P<0.05 compared to saline-pretreated mice subjected to SSI (Mann–Whitney U-test). CFU, colony forming units; CLP, cecal ligation and puncture; MSI, moderate septic injury; ONOO⁻, peroxynitrite; s.c., subcutaneously; SSI, severe septic injury; UA, uric acid.