Figure 4.

Effect of avarol-3′-thiosalicylate and the reference inhibitor LY311727 (LY) on sPLA₂ activity. (a) Concentration-effect relationship for the inhibition of synovial recombinant sPLA₂ activity. Data represents mean±s.e.mean, n=6. ^*P<0.05, ^**P<0.01 significantly different from control sPLA₂ activity (3144.0±120.7 pmol of oleic acid mg⁻¹ min⁻¹). (b) Effect on sPLA₂ activity determined in supernatants from HaCaT cells incubated during 24 h. ^*P<0.05, ^**P<0.01 significantly different from untreated cells (C).