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. Author manuscript; available in PMC: 2008 Sep 7.
Published in final edited form as: Brain Res. 2007 Jul 17;1168:46–59. doi: 10.1016/j.brainres.2007.06.066

Figure 3.

Figure 3

The number of CD68 immunoreactive (IR) macrophages increased in L4 dorsal root ganglia (DRG) following intravenous paclitaxel administration. L4 DRG sections from vehicle (cremephor/ethanol) (A) and paclitaxel-treated rats (B-D) were examined immunohistochemically with an antibody against CD68 (clone ED1), an intracellular lysosomal protein that is expressed in activated macrophages. The number of CD68-IR macrophages increased in L4 DRG of paclitaxel treated rats beginning on day 6 through day 10. DRG sections from paclitaxel-treated rats day 4 (B) or earlier time points displayed similar numbers of CD68-IR macrophages compared to vehicle-treated rats (A). Note that CD68-IR macrophages in paclitaxel-treated rats were larger in size and formed aggregates around neuronal cell bodies (D). CD68-IR macrophages in vehicle-treated rats (C) were evenly dispersed throughout the DRG and were morphologically long and slender in appearance. Scale bars: A-D = 30 μm.