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. Author manuscript; available in PMC: 2008 Sep 7.
Published in final edited form as: Brain Res. 2007 Jul 17;1168:46–59. doi: 10.1016/j.brainres.2007.06.066

Figure 4.

Figure 4

Activating transcription factor 3 (ATF3) is upregulated in Schwann cells and the number of CD68-IR macrophages increases in the sciatic nerve of rats following paclitaxel administration. Sciatic nerve sections from midthigh level were immunohistochemically labeled with antibodies against S100β (blue) which labels the outermost portion of myelinating Schwann cells and ATF3 (red). The number of ATF3-IR S100β-IR within the sciatic nerve of paclitaxel-treated rats increased at day six (C) and day 10 (E) following paclitaxel administration compared to vehicle-treated rats (A). Note that Schwann cells expressing ATF-3 appeared to be grouped in a linear arrangement (arrowheads) as if a group of Schwann cells that ensheath the same injured axon upregulated ATF3. Similarly, the number and size of CD68-IR macrophages was greater in the sciatic nerve of paclitaxel-treated rats at day 10 (F) compared to vehicle-treated rats (B). The number of CD68-IR macrophages in the sciatic nerve of paclitaxel-treated rats at day 6 (D) and earlier time points was similar compared to vehicle-treated rats (B) Scale bars A-F = 20 μm.