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. Author manuscript; available in PMC: 2008 Sep 7.
Published in final edited form as: Brain Res. 2007 Jul 17;1168:46–59. doi: 10.1016/j.brainres.2007.06.066

Table 1. Evolving cellular pathology in dorsal root ganglia (L4), sciatic nerve and spinal cord following intravenous paclitaxel in the rat.

Summary of quantification of cellular changes in paclitaxel-treated rats compared to values obtained from vehicle-treated rats at the same time point. For immunofluorescence measurements results are as follows: Horizontal arrows no significant change, one arrow 100-200% increase, two arrows 200-300% increase, three arrows 300-400 % increase, four arrows more than 500% increase compared to relative vehicle values. For counts of neuronal ATF3 expression in the DRG, low or null levels in vehicle-treated rats made calculating fold increase from vehicle values difficult. Therefore, arrows indicate actual values as percentage of total neurons labeled in L4 ganglia of paclitaxel treated rats. Horizontal arrows no significant ATF3 expression, one arrow 1-5%, two arrows 5-10%, three arrows 10-20%, and four arrows greater than 20% (complete values for experimental and control rats are in text).

Time post-injection
Day 1 Day 4 Day 6 Day 10
DRG
 Neurons (ATF3, %) ↗ ↗↗↗↗ ↗↗↗↗ ↗↗
 Satellite cells (GFAP, IF) ↔ ↔ ↗↗↗↗ ↗↗↗↗
 Macrophages (CD68, #) ↔ ↔ ↗↗ ↗↗↗↗
 Nodule of Nagoette (GFAP/ATF3, #) ↔ ↔ ↔ ↗↗↗↗
Sciatic nerve
 Schwann cell (GFAP, IF) ↔ ↔ ↔ ↔
 Schwann cell (S100β/ATF3, #) ↔ ↔ ↗ ↗↗
 Macrophages (CD68, #) ↔ ↔ ↔ ↗↗↗↗
Spinal cord
 Astrocyte (GFAP, IF)
  Laminae I-II ↔ ↔ ↗ ↗
  Laminae III-VI ↔ ↔ ↗ ↗
 Microglia (CD11b, IF)
  Laminae I-II ↔ ↔ ↔ ↔
  Laminae III-VI ↔ ↔ ↗ ↗↗↗
 Neurons (ATF3, #) ↔ ↔ ↔ ↔