Table 1.
Relative frequency and age/stage/risk correlates of cytogenetic abnormalities
| Karyotype features | Frequencies (%) | Overepresented group (P value) | ||
| Ploidy level | Age | Stage | Risk | |
| 2n | 59 | - | - | - |
| 3n | 23 | <1 ys (6 × 10-4) | 1–2 (4 × 10-5) | L (1 × 10-4) |
| 4n | 15 | - | - | - |
| Whole chromosome gains | ||||
| +17 | 15 | <1 ys (3 × 10-4) | 1–2 (4 × 10-5) | L (7 × 10-6) |
| +7 | 13 | - | - | - |
| +18 | 11 | - | - | - |
| +12 | 10 | <1 ys (3 × 10-3) | 1–2 (2 × 10-4) | L (2 × 10-4) |
| +20 | 9 | - | - | - |
| +13 | 9 | - | - | - |
| +9 | 8 | <1 ys (2 × 10-4) | 1–2 (2 × 10-8) | L (3 × 10-7) |
| +6 | 7 | - | - | - |
| +8 | 7 | - | - | - |
| +21 | 6 | - | - | - |
| +5 | 6 | - | - | - |
| +11 | 5 | - | - | - |
| +2 | 5 | - | - | - |
| +1 | 5 | - | - | - |
| Whole chromosome losses | ||||
| -X | 21 | - | - | - |
| -11 | 14 | - | - | - |
| -10 | 14 | - | - | - |
| -15 | 14 | - | - | - |
| -19 | 14 | - | - | - |
| -4 | 14 | - | 1–2 (5 × 10-4) | L (5 × 10-4) |
| -3 | 12 | - | - | - |
| -9 | 11 | - | - | - |
| -14 | 11 | - | - | - |
| -17 | 11 | - | - | - |
| -22 | 11 | - | - | - |
| -21 | 11 | - | - | - |
| -13 | 10 | - | - | - |
| -16 | 10 | - | - | - |
| -8 | 9 | - | - | - |
| -6 | 9 | - | - | - |
| -20 | 9 | - | - | - |
| -5 | 8 | - | - | - |
| -2 | 6 | - | - | - |
| -18 | 6 | - | - | - |
| -12 | 5 | - | - | - |
| Partial chromosome gains | ||||
| +1q (1p31q44) | 15 | - | - | - |
| +17q (17q12q25) | 13 | - | - | - |
| Partial chromosome losses | ||||
| 1p- (1p36p11) | 48 | - | - | H (4 × 10-3) |
| 11q- (11q23q25) | 8 | - | - | - |
| 3p- (3p26p12) | 8 | - | - | - |
| 6q- (6q23q27) | 6 | - | - | - |
| Gene amplifications | ||||
| dmin | 20 | 1–3 (8 × 10-5) | - | H (6 × 10-3) |
| hsr | 6 | - | - | - |
Over-representation tested by Chi-Square test with significance level set at P < 0.01. Abbreviations: ys, years; L, low risk; H, high risk; -, not significantly over-represented in any subgroup.