TABLE 1.
Comparative efficacies of AM 7359 and linezolid against MSSA Smith in an organ burden assay
| Compound (mode of administration) and MIC (μg/ml) | Dose (mg/kg/day) | % Mortalitya | Log CFU/g of kidneyb (% eradication) | Reduction (SD)c |
|---|---|---|---|---|
| AM 7359 (p.o.), 0.125 | 25 | 0 | 3.11* (0) | 5.23 (0.58) |
| 12.5 | 0 | 5.41* (0) | 2.93 (0.59) | |
| 6.25 | 0 | 5.71* (0) | 2.63 (0.80) | |
| 3.12 | 0 | 8.60 (0) | −0.26 (0.37) | |
| Linezolid (p.o.), 2.0 | 25 | 0 | 2.27* (100) | 6.07 (0.04) |
| 12.5 | 0 | 5.63* (0) | 2.71 (0.37) | |
| 6.25 | 0 | 6.90* (0) | 1.44 (0.59) | |
| 3.12 | 0 | 8.87 (0) | −0.53 (0.10) | |
| AM 7359 (i.v.), 0.125 | 25 | 0 | 3.81* (0) | 4.59 (0.15) |
| 12.5 | 0 | 3.94* (0) | 4.46 (0.16) | |
| 6.25 | 0 | 6.37* (0) | 2.03 (0.61) | |
| 3.12 | 0 | 8.34 (0) | 0.06 (0.15) | |
| Linezolid (i.v.), 2.0 | 25 | 0 | 4.13* (0) | 4.27 (0.70) |
| 12.5 | 0 | 6.96* (0) | 1.44 (1.62) | |
| 6.25 | 0 | 8.52 (0) | −0.12 (0.20) | |
| 3.12 | 0 | 8.67 (0) | −0.27 (0.11) | |
| Control (distilled H2O; p.o.) | 20 | 8.34 (0) | ||
| Control (distilled H2O; i.v.) | 0 | 8.40 (0) |
a
Calculated as the number dead divided by the total number in the group.
b
*, significant reduction compared to sham-treated control as determined by Student's t test.
c
Reduction in log number of CFU compared to sham-treated control. Significant reductions are shown in bold. SD, standard deviation of results for the four mice per group.