TABLE 2.
Decline in bacterial counts in peritoneal fluid and blood samples of animals with pneumococcal peritonitis-sepsis after 4 h posttherapy compared to those of controls
| Test group (dose [mg] per mouse) | Injection route | Mean ± SD differences in bacterial counts (log10 CFU/ml)a
|
|
|---|---|---|---|
| Peritoneal fluid | Blood | ||
| LytA (1.7) | i.p. | −5.4 ± 0.6b | −5.4 ± 1.3b |
| i.v. | −3.5 ± 0.9b | −4.3 ± 1.0b | |
| Cpl-1 (1.4) | i.p. | −4.8 ± 0.7b | −3.5 ± 0.9 |
| i.v. | −0.7 ± 0.6 | −1.1 ± 0.3 | |
| Cpl-1 (3.3) | i.p. | −5.2 ± 0.3b | −4.2 ± 0.5b |
| i.v. | −1.5 ± 0.5b | −1.8 ± 0.3 | |
| CTX (12) | i.p. | −3.5 ± 0.6b | −4.5 ± 1.7b |
| i.v. | −3.1 ± 1.3b | −4.1 ± 1.6 | |
a
Differences in bacterial titers between treated animals and untreated controls.
b
Statistically significant differences compared with the results for the controls (P < 0.05).