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Sensitivities of recombinant mutant viruses to RSV604
| Virus | RSV604 EC50 (μM)a | Fold increase in resistanceb |
|---|---|---|
| WT | 0.96 ± 0.04 | 1.0 |
| M2 | 1.14 ± 0.41 | 1.2 |
| N105D mutant | 4.78 ± 0.93 | 5.0 |
| I120L mutant | 6.03 ± 0.50 | 6.3 |
| L139I mutant | 6.70 ± 0.80 | 7.0 |
| I129L-plus-L139I mutant | >20 | >20 |
Data are means ± SD for three separate plaque reduction assays.
Compared to the WT virus control.
