TABLE 1.

In vitro activities of telavancin and comparators against gram-positive bacteria

Organism (no. of strains) and antimicrobial agent	MIC (mg/liter)
	Range	50%	90%
Staphylococcus aureus
Methicillin susceptible (60)
Telavancin	0.06-0.5	0.25	0.25
Vancomycin	0.5-2	0.5	1
Teicoplanin	0.25-4	0.5	1
Daptomycin	0.12-0.5	0.25	0.5
Oxacillin	≤0.06-2	0.25	0.5
Erythromycin	≤0.12->16	0.5	>16
Telithromycin	0.06->8	0.12	0.12
Clindamycin	≤0.5->4	≤0.5	≤0.5
Quinupristin-dalfopristin	≤0.12-0.5	0.25	0.25
Linezolid	≤0.5-4	2	2
Ciprofloxacin	0.12->8	0.25	1
Trimethoprim-sulfamethoxazole	≤0.5-2	≤0.5	≤0.5
Gentamicin	≤0.06->16	0.25	1
Methicillin resistant (40)
Telavancin	0.06-0.5	0.25	0.25
Vancomycin	0.5-2	1	1
Teicoplanin	≤0.12-4	0.5	4
Daptomycin	0.12-1	0.5	0.5
Oxacillin	4->4	>4	>4
Erythromycin	≤0.12->16	>16	>16
Telithromycin	≤0.03->8	0.12	>8
Clindamycin	≤0.5->4	≤0.5	>4
Quinupristin-dalfopristin	≤0.12->4	0.25	0.5
Linezolid	≤0.5-4	2	2
Ciprofloxacin	0.25->8	>8	>8
Trimethoprim-sulfamethoxazole	≤0.5->4	≤0.5	>4
Gentamicin	0.12->16	0.5	>16
CoNS
Methicillin susceptible (30)
Telavancin	0.12-0.25	0.25	0.25
Vancomycin	0.5-2	1	2
Teicoplanin	≤0.12-16	2	8
Daptomycin	0.12-1	0.5	1
Oxacillin	≤0.06-0.25	0.12	0.12
Erythromycin	≤0.12->16	0.25	>16
Telithromycin	≤0.03->8	0.06	0.5
Clindamycin	≤0.5->4	≤0.5	≤0.5
Quinupristin-dalfopristin	≤0.12-0.25	≤0.12	0.25
Linezolid	1-2	1	2
Ciprofloxacin	0.12->8	0.12	0.25
Trimethoprim-sulfamethoxazole	≤0.5->4	≤0.5	>4
Gentamicin	≤0.06->16	≤0.06	≤0.06
Methicillin resistant (50)
Telavancin	0.12-0.5	0.25	0.25
Vancomycin	0.5-4	1	2
Teicoplanin	≤0.12-16	2	8
Daptomycin	0.12->1	0.5	0.5
Oxacillin	0.5->4	>4	>4
Erythromycin	≤0.12->16	>16	>16
Telithromycin	0.06->8	0.12	>8
Clindamycin	≤0.5->4	≤0.5	>4
Quinupristin-dalfopristin	≤0.12->4	0.25	0.5
Linezolid	1-4	2	2
Ciprofloxacin	≤0.06->8	2	>8
Trimethoprim-sulfamethoxazole	≤0.5->4	2	>4
Gentamicin	≤0.06->16	8	>16
Enterococcus faecalis
Vancomycin susceptible (73)
Telavancin	≤0.015-0.5	0.25	0.5
Vancomycin	≤0.5-4	2	2
Teicoplanin	≤0.03-0.25	0.12	0.25
Daptomycin	≤0.015-4	1	2
Ampicillin	≤0.25-8	1	2
Linezolid	1-4	2	2
Quinupristin-dalfopristin	0.5-32	8	16
Ciprofloxacin	0.5->32	1	>32
Vancomycin resistant (7)
Telavancin	0.25-8	4	8
Vancomycin	64->512	512	>512
Teicoplanin	0.06->128	32	>128
Daptomycin	0.5-2	0.5	2
Ampicillin	1-4	1	4
Linezolid	1-2	2	2
Quinupristin-dalfopristin	8-16	8	16
Ciprofloxacin	0.5->32	1	>32
Enterococcus faecium
Vancomycin susceptible (59)
Telavancin	0.03-0.5	0.12	0.25
Vancomycin	≤0.5-2	1	1
Teicoplanin	≤0.03-2	0.25	0.5
Daptomycin	0.03-4	2	4
Ampicillin	0.5->128	64	128
Linezolid	1-4	2	2
Quinupristin-dalfopristin	0.25-4	1	4
Ciprofloxacin	0.25->32	>32	>32
Vancomycin resistant (21)
Telavancin	0.12-8	1	2
Vancomycin	8->512	512	512
Teicoplanin	0.12->128	32	128
Daptomycin	0.25-4	2	2
Ampicillin	1->128	128	128
Linezolid	1-2	2	2
Quinupristin-dalfopristin	0.25-4	1	4
Ciprofloxacin	0.5->32	32	>32
Streptococcus pneumoniae
Penicillin susceptible (42)
Telavancin	0.008-0.06	0.015	0.03
Vancomycin	0.25-0.5	0.25	0.5
Daptomycin	0.06-0.5	0.12	0.25
Penicillin	≤0.06-≤0.06	≤0.06	≤0.06
Cefuroxime	≤0.12-0.25	≤0.12	≤0.12
Ceftriaxone	≤0.015-0.12	0.03	0.03
Erythromycin	≤0.015->1	0.03	0.06
Telithromycin	0.004-0.25	0.008	0.008
Clindamycin	≤0.03->0.25	0.06	0.06
Levofloxacin	0.25-1	0.5	1
Trimethoprim-sulfamethoxazole	0.12->4	0.25	1
Linezolid	0.5-1	1	1
Tetracycline	≤0.06->8	0.12	0.25
Penicillin intermediate (36)
Telavancin	0.008-0.06	0.015	0.03
Vancomycin	0.25-0.5	0.25	0.5
Daptomycin	≤0.03-0.5	0.12	0.25
Penicillin	0.12-1	0.5	1
Cefuroxime	≤0.12->4	0.5	4
Ceftriaxone	0.03-1	0.12	1
Erythromycin	≤0.015->1	0.03	>1
Telithromycin	≤0.002	0.008	0.25
Clindamycin	≤0.03->0.25	0.06	>0.25
Levofloxacin	0.5-2	0.5	1
Trimethoprim-sulfamethoxazole	0.12->4	4	>4
Linezolid	0.5-2	1	1
Tetracycline	≤0.06->8	0.25	>8
Penicillin resistant (22)
Telavancin	0.015-0.03	0.015	0.03
Vancomycin	0.25-0.5	0.25	0.5
Daptomycin	0.06-0.25	0.12	0.12
Penicillin	2->2	2	2
Cefuroxime	4->4	>4	>4
Ceftriaxone	0.5-2	1	2
Erythromycin	0.03->1	>1	>1
Telithromycin	0.008-0.5	0.015	0.03
Clindamycin	0.06->0.25	>0.25	>0.25
Levofloxacin	0.5-8	0.5	4
Trimethoprim-sulfamethoxazole	0.12->4	4	>4
Linezolid	0.5-1	1	1
Tetracycline	0.12->8	0.25	>8
Streptococcus group A (60)
Telavancin	0.03-0.06	0.03	0.06
Vancomycin	0.25-0.5	0.25	0.5
Daptomycin	≤0.03-0.5	0.06	0.06
Penicillin	≤0.06-≤0.06	≤0.06	≤0.06
Cefuroxime	≤0.12-≤0.12	≤0.12	≤0.12
Ceftriaxone	≤0.015-0.06	0.03	0.03
Erythromycin	0.03->1	0.03	0.06
Telithromycin	0.008->4	0.015	0.015
Clindamycin	≤0.03->0.25	≤0.03	0.06
Levofloxacin	≤0.12-1	0.5	0.5
Trimethoprim-sulfamethoxazole	≤0.06-0.25	≤0.06	0.25
Linezolid	0.5-1	1	1
Tetracycline	0.12->8	0.12	>8
Streptococcus group B (60)
Telavancin	0.03-0.12	0.06	0.06
Vancomycin	0.25-1	0.5	0.5
Daptomycin	0.06-0.5	0.25	0.25
Penicillin	≤0.06-≤0.06	≤0.06	≤0.06
Cefuroxime	≤0.12-0.5	≤0.12	≤0.12
Ceftriaxone	0.03-0.12	0.06	0.06
Erythromycin	0.03->1	0.03	0.5
Telithromycin	0.008-0.12	0.015	0.015
Clindamycin	≤0.03->0.25	0.06	0.06
Levofloxacin	0.25-1	0.5	1
Trimethoprim-sulfamethoxazole	≤0.06-0.25	≤0.06	0.12
Linezolid	0.5-1	1	1
Tetracycline	0.12->8	>8	>8
Viridans streptococci (60)
Telavancin	0.015-0.12	0.06	0.06
Vancomycin	0.25-1	0.5	1
Daptomycin	≤0.03->1	0.5	1
Penicillin	≤0.06->2	≤0.06	2
Cefuroxime	≤0.12->4	≤0.12	2
Ceftriaxone	≤0.015-4	0.12	2
Erythromycin	≤0.015->1	0.03	>1
Telithromycin	≤0.002-0.25	0.008	0.12
Clindamycin	≤0.03->0.25	≤0.03	>0.25
Levofloxacin	0.25->8	0.5	1
Trimethoprim-sulfamethoxazole	≤0.06->4	0.25	2
Linezolid	0.25-2	1	1
Tetracycline	≤0.06->8	0.5	>8