TABLE 1.

Strain characteristics

Strain	Serotype	Levofloxacin MIC (μg/ml)	Mutation			Mutation rate	95% Confidence limit
			parC	gyrA	parE		Upper	Lower
In vitro
Hex-deficient mutant	2	0.5				6.2 × 10−8	9.2 × 10−8	4.3 × 10−8
D39-2	2	16		S81F	D435N	4.7 × 10−9	1.2 × 10−8	1.8 × 10−9
D39-3	2	>32	S79Y	S81F		1.6 × 10−8	3.9 × 10−8	6.8 × 10−9
D39-19	2	16	D83N	S81Y		9.2 × 10−9	2.1 × 10−8	4.1 × 10−9
Clinical
D39	2	0.5				1.4 × 10−8	2.6 × 10−8	7.5 × 10−9
2530	35B	8	D83N	S81F		1.2 × 10−7	2.1 × 10−7	7.2 × 10−8
1237	6B	8	S79F	S81Y		9.4 × 10−8	1.2 × 10−7	7.4 × 10−8
455	9N	>32	S79Y	S81F		2.0 × 10−8	4.3 × 10−8	1.4 × 10−8
3386	34	>32	S79F	S81F		2.7 × 10−8	6.5 × 10−8	1.1 × 10−8