TABLE 2.

Dosing regimens and corresponding %^fT_>MIC values based on mouse and human pharmacokinetics resulting in a net static effect after 24 h of simulating growth and kill kinetics^a

Regimen	Mouse		Human
	Dose (mg/kg of body wt)	%fT>MIC	Dose (mg)	%fT>MIC
q2	2.12	37.3	ND	ND
q3	4.60	38.1	ND	ND
q4	9.29	37.6	20.2	23.7
q6	35.6	36.5	38.9	36.3
q8	129.7	35.7	59.8	37.9
q12	−	−	121.0	37.7

^aq2, dose every 2 h; ND, not done; −, static dose could not be determined within the dosing range.