TABLE 3.
Phenotypes and genotypes among 125 erythromycin-resistant S. pneumoniae isolates
| Phenotype (no. of isolates) | PCR detection of gene
|
Presumed transposon | Serotypes (no. of isolates) | PFGE pattern (no. of isolates) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| erm(B) | mef(E) | mef(A) | tet(M) | aph3′-III | int | xis | tnpR | tnpA | ||||
| MLSB (109) | + | − | − | + | − | − | − | − | − | Tn1116 | 19F (8), 15A (4), 19A (2) | Sweden15A-25 (14)a |
| + | − | − | + | − | − | − | − | − | Tn1116 | 19F (2),a 6B (1) | Unrelated (3) | |
| + | − | − | + | − | + | + | + | + | Tn3872 | 19F (6) | Clone19F-C (6) | |
| + | − | − | + | − | + | + | + | + | Tn3872 | 23F (3), 19A (1) | Spain23F-1 (4) | |
| + | − | − | + | − | + | + | + | + | Tn3872 | 6B (2) | Spain6B-2 (2) | |
| + | − | − | + | − | + | + | + | + | Tn3872 | 19A (2) | Clone19A-O (2) | |
| + | − | − | + | − | + | + | + | + | Tn3872 | 14 (1) | Spain9V-3 (1) | |
| + | − | − | + | − | + | + | + | + | Tn3872 | 14 (1) | Spain14-5 (1) | |
| + | − | − | + | − | + | + | + | + | Tn3872 | 19F (2), 6A (1), 14 (1), NT (3) | Unrelated (7) | |
| + | − | − | + | + | + | + | + | + | Tn917 plus Tn1545 | 19F (1) | Clone19F-C (1) | |
| + | − | − | + | + | + | + | + | + | Tn917 plus Tn1545 | 19A (1), NT (1) | Unrelated (2) | |
| + | − | − | + | − | + | + | − | − | Tn6002 | 19F (6) | Clone19F-C (6) | |
| + | − | − | + | − | + | + | − | − | Tn6002 | 19A (1) | Clone19A-O (1) | |
| + | − | − | + | − | + | + | − | − | Tn6002 | 23F (5), 19F (3) | Spain23F-1 (8) | |
| + | − | − | + | − | + | + | − | − | Tn6002 | 6B (6) | Spain6B-2 (6) | |
| + | − | − | + | − | + | + | − | − | Tn6002 | 19A (3) | Clone19A- Z (3) | |
| + | − | − | + | − | + | + | − | − | Tn6002 | 23A (3), 23F (1) | Clone23A-Y (4) | |
| + | − | − | + | − | + | + | − | − | Tn6002 | 14 (1) | Spain9V-3 (1) | |
| + | − | − | + | − | + | + | − | − | Tn6002 | 6B (2) | Poland6B-20 (2) | |
| + | − | − | + | − | + | + | − | − | Tn6002 | 19A (4), 19F (2), 23F (1), 6B (2), 16 (2), 15A (1), NT (3) | Unrelated (15) | |
| + | − | − | + | + | + | + | − | − | Tn1545 | 19A (4) | Clone19A- Z (4) | |
| 19A (1), 6A (1) | Unrelated (2) | |||||||||||
| + | + | − | + | + | + | + | − | − | Tn1545 plus mega | 19A (1) | Clone19A- Z (1) | |
| + | + | − | + | − | + | + | − | − | Tn6002 plus mega | 23F (1) | Clone23A-Y (1) | |
| + | + | − | + | − | + | + | − | − | Tn6002 plus mega | 24 (1), 33 (1) | Unrelated (2) | |
| + | + | − | + | − | + | + | + | + | Tn3872 plus mega | 19F (1), 19A (1)b | Unrelated (2) | |
| + | − | − | −b | − | + | + | − | − | 6B (1) | Spain6B-2 (1) | ||
| + | − | − | −b | − | + | + | − | − | 11 (1), 21 (1), NT (2) | Unrelated (4) | ||
| + | − | − | −b | − | − | − | − | − | 23F (1), 35B (1), 5 (1) | Unrelated (3) | ||
| M (16) | − | + | − | −b | − | − | − | − | − | mega | 14 (6) | Spain9V-3 (6) |
| − | + | − | −b | − | − | − | − | − | mega | 15B (2), 29 (1), 6A (1), 6B (1), NT (2) | Unrelated (7) | |
| − | − | + | −b | − | − | − | − | − | Tn1207.1 | 14 (2) | England14-9 (2) | |
| − | + | − | + | − | + | + | − | − | Tn916 plus mega or Tn2009 | NT (1) | Unrelated (1) | |
a
Positive detection of tndX gene.
b
Tetracycline-susceptible strains.