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Alignment of the protease amino acid sequence (A) and gag p7/p1 and p1/p6 cleavage sites (B) from the HIV-2 isolates. The dots represent homology to the reference strain HIV-1NL4-3. A letter indicates an amino acid substitution relative to the reference. Underlined amino acids are those associated with a decreased susceptibility to PIs in HIV-1, and arrows point to the positions where mutations were observed after LPV selection in the current study.
