FIG. 2.

The ex vivo dermatophyte skin infection model responds to drug treatment. Skin samples colonized with T. mentagrophytes (DUMC160.03) were treated every 2 days (days 0, 2, 4, and 6) with 2× MIC of fluconazole, terbinafine, FK506, or CsA. Samples were fixed at the indicated times. A significant reduction in hyphal colonization and intact skin was observed by day 7 p.i., demonstrating the efficacy of fluconazole or terbinafine. FK506 or CsA treatment did not result in hyphal clearing or improved skin integrity.