FIG. 3.

T. mentagrophytes is susceptible to drug combinations in the ex vivo infection model. The antifungal activity of fluconazole was enhanced by FK506 or CsA. (A) Fluconazole was more effective by day 3 p.i. when combined with FK506 or CsA (compare with Fig. 2). The accelerated hyphal clearing observed when drugs were combined at lower concentrations was indicative of drug synergy. (B) Samples treated with terbinafine-CsA or terbinafine-FK506 combinations were indistinguishable from those treated with terbinafine alone (Fig. 2). FLC, fluconazole; TRB, terbinafine. Bars, 5 μm (unless otherwise indicated).