TABLE 1.
Experimentally obtained pharmacokinetic parameters in β-lactamase-negative simulations and T>MICs
| Pharmacokinetic parameter | Cefditoren
|
Amoxicillin
|
Clavulanic acid
|
|||
|---|---|---|---|---|---|---|
| Total | Free | Total | Free | Total | Free | |
| Mean Cmax (μg/ml) ± SD | 4.1 ± 0.3 | 0.5 ± 0.0 | 17.2 ± 0.6 | 13.6 ± 0.7 | 2.1 ± 0.2 | 1.5 ± 0.1 |
| Mean Tmax (h) ± SD | 2.8 ± 0.0 | 2.8 ± 0.0 | 1.5 ± 0.0 | 1.5 ± 0.0 | 1.5 ± 0.0 | 1.5 ± 0.0 |
| Mean t1/2 (h) ± SD | 1.6 ± 0.05 | 1.5 ± 0.1 | 1.3 ± 0.1 | 1.4 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 |
| Mean AUC0-24 (μg/ml·h) ± SD | 14.8 ± 0.3 | 1.9 ± 0.3 | 73.1 ± 1.2 | 60.7 ± 3.3 | 4.7 ± 0.2 | 2.9 ± 0.1 |
| T>MIC indexa | ||||||
| Ampicillin susceptible | 100 | 100 | 65.4 | 63.3 | ||
| BLNAR | 99.3 | 44.1 | 34.6 | 28.3 | ||
| BLPACR | 100 | 62.5 | 34.6 | 28.3 | ||
a
Expressed as the percent dosing interval. The value was determined on an amoxicillin basis in the case of the amoxicillin-clavulanic MIC.