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. 2007 Aug 6;51(10):3760–3762. doi: 10.1128/AAC.00488-07

FIG. 1.

FIG. 1.

Residual fungal burden from the Monte Carlo simulations following the administration of amphotericin B alone at 0.1, 0.3, and 0.6 mg/kg (A, C, and E) and the additional fungicidal effect induced by combination with 25 mg/kg 5FC (B and D) and 100 mg/kg 5FC (E). The addition of 5FC at 25 mg/kg to amphotericin B at 0.1, 0.3, and 0.6 mg/kg resulted in further declines in fungal burden of 0.7, 0.15, and 0.1 log10 CFU/g, respectively (B, D, and F). The effect induced by the addition of 5FC becomes progressively smaller with higher dosages of amphotericin B with the induction of near-maximal effect. The use of 5FC at 100 mg/kg did not result in a further decline in fungal burden to that observed with 5FC at 25 mg/kg because %TMIC is 100% for both regimens (G and H). SD, standard deviation.