TABLE 3.
Correlation of dose/MIC ratios and their conversion to AUC/MICa and fAUC/MICb ratios versus outcomes for patients with candidemia or OPC for EUCAST discussion document 7.1
| Dose/MIC | AUC/MIC | fAUC/MIC | Range of doses (mg/day) administered | Range of MICs (mg/liter) of isolates | % Clinical success (no. cured/total no.) in patients with:
|
||
|---|---|---|---|---|---|---|---|
| Candidemia | OPC | All | |||||
| 400-4,800 | 359-4,678 | 316-4,117 | 100-800 | 0.12-1.0 | 92 (102/111) | 100 (5/5) | 92 (107/116) |
| 150-200 | 146-189 | 129-166 | 100-600 | 0.5-4.0 | 100 (3/3) | 100 (21/21) | 100 (24/24) |
| 100 | 90 | 79 | 100-800 | 1.0-8.0 | 100 (4/4) | 100 (5/5) | 100 (9/9) |
| 50 | 45 | 40 | 100-400 | 2.0-8.0 | 33 (1/3) | 57 (4/7) | 50 (5/10) |
| 25 | 22 | 20 | 100-200 | 4.0-16.0 | 50 (1/2) | 21 (8/38) | 22.5 (9/40) |
| 12.5 | 11 | 10 | 100-400 | 8.0-32.0 | 100 (1/1) | 0 (0/37) | 2.6 (1/38) |
| ≤6.25 | 6 | 5 | 200 | 32.0 | 50 (1/2) | 0 (0/19) | 4.7 (1/21) |
a
The AUC/MIC values were obtained after application of the following equation: AUC = 0.99 × dose − 9.2.
b
fAUC/MIC was calculated by taking into consideration that the f of fluconazole is 88%.