FIG. 5.

Effects of drugs on the intracellular replication of B. suis in human macrophage-like THP1 cells. Brucella growth within untreated cells (•) or in the presence of 25 μM of various drugs (▪). Shown are results for drug 5c (A), drug 5d (B), drug 5e (C), drug 5i (D), and drug 5n (E). Drugs were added to the infected macrophages at 90 min postinfection. The experiments were performed in triplicate. Error bars indicate standard deviation. Student's t test revealed that differences were always significant at 24 h (P ≤ 0.001, except for panel E [P < 0.05]).