TABLE 1.
Effects of pretreatment of sintered HA plates with polymers on saliva-promoted S. mutans adhesion
| Expt | Pretreatment | l/m/na | rb | qc | MW (104) | Concn (mg/ml) | Saliva treatment | Mean S. mutans adhesion (106 CFU) ± SEMd |
|---|---|---|---|---|---|---|---|---|
| 1 | dW | - | 5.0 ± 0.6‡ | |||||
| dW | + | 21.7 ± 0.9 | ||||||
| Polymer A | 31/16/53 | 10 | 120 | 1.6 | 1 | + | 12.3 ± 1.0† | |
| 5 | + | 5.9 ± 0.2‡ | ||||||
| 25 | + | 6.2 ± 0.9‡ | ||||||
| 2 | dW | - | 8.2 ± 4.5* | |||||
| dW | + | 26.0 ± 0.8 | ||||||
| Polymer B | 77/15/8 | 10 | 120 | 1.5 | 10 | + | 11.0 ± 2.2† | |
| Polymer C | 45/44/11 | 10 | 120 | 2 | 10 | + | 19.9 ± 0.2† | |
| Polymer D | 58/25/17 | 2 | 120 | 2.2 | 10 | + | 23.7 ± 0.6e | |
| 3 | dW | - | 3.5 ± 0.3‡ | |||||
| dW | + | 16.3 ± 0.8 | ||||||
| Polymer E | 87/13/0 | 10 | 120 | 10.9 | 10 | + | 4.8 ± 0.6‡ | |
| Polymer F | 42/58/0 | 10 | 90 | 10.3 | 10 | + | 8.5 ± 1.1† | |
| Polymer G | 39/61/0 | 10 | 90 | 3.5 | 10 | + | 6.8 ± 0.5‡ | |
| 4 | dW | - | 6.7 ± 0.5‡ | |||||
| dW | + | 31.6 ± 0.8 | ||||||
| Polymer H | 24/76/0 | 10 | 120 | 2.9 | 10 | + | 9.8 ± 1.0‡ | |
| Polymer I | 42/58/0 | 10 | 120 | 2.8 | 10 | + | 6.9 ± 0.6‡ | |
| Polymer J | 39/61/0 | 10 | 23 | 2.7 | 10 | + | 17.1 ± 1.7† | |
| Polymer K | 87/13/0 | 10 | 120 | 3.2 | 10 | + | 7.2 ± 2.3‡ | |
| Polymer L | 90/10/0 | 10 | 23 | 5.1 | 10 | + | 18.1 ± 3.9* |
a
l/m/n, Molar ratio of methacryloyloxyalkyl phosphate/PEG/methacrylate groups (see Fig. 1).
b
r, Number of methyl groups (linker length) between methacryloyl and phosphate groups.
c
q, Number of ethoxy groups of PEG.
d
Unpaired Student t tests after a preliminary F test of the homogeneity of within-group variance were conducted between dW-pretreated, saliva-treated, and saliva-untreated or polymer-pretreated groups. *, P < 0.05; †, P < 0.01; ‡, P < 0.001.
e
Not significant (P > 0.05).