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Effect of CZX dosing frequency on the total and CZX-resistant populations of E. cloacae 22491 isolated from mixed-infection abscesses. Dosing regimens of 6 to 1,536 mg/kg/day were started 30 min before inoculation and continued for 24 h. Daily doses were divided into different dosing regimens given q2h, q4h, or q6h. The total bacterial population was isolated on antibiotic-free medium, and the resistant population was isolated on medium containing 16× the MIC of CZX.
